The purpose of this study was to test potential cariostatic benifit of dentifrices containing both fluoride(F) and sanguinaria (SG) in a silica abrasive formula using microbial remin/demin cycle model. Subsurface lesion on bovine extracted enamel specimens were prepared by exposing to a lactate Carbopol buffer system for 44-hours. The specimens were assigned to 7 test groups of 12 specimens each by randomized blocks with VHN stratification. The test groups were a placebo,- 2 NaF-silica dentifrice (with and without SG) and four MFP-DCPD dentifrices(different F level). -Negative and positive control dentifrices were selected by the guidelines of the American- Dental Association. The microbial cyclic sequence and pre- and post-treatment assays were same as described previously[ Hong et al., J Dent Res 75:232, 1996].
The results of A VHN Mean ± S.E. for each group were; placebo, 26.70 ± 2.54; MFP(250ppm F)/DCPD, 42.34±1.90; MFP(1,000 ppm F) plus 2.0% Bamboo Salt(BS,Jukyom)/DCPD, 44.70±4.34; MFP(1,000 ppm F)/DCPD(Fresh Mint), 46.20± 2.46; MFP(1,100 ppm F)/DCPD (Colgate), 55.82±4.18; NaF(1,100 ppm)/Silica(Cerst), 84.98±4.17; NaF(1,000 ppm)/Silica plus 0.1% SG(Denta Q), 92.16±5.21. The data were
then statistically analyzed using ANOVA for the significance of differences among treatment groups. A VHNs for groups treated with dentifrices containing 1,000 ppm F from MFP with or without BS were significantly higher than the placebo. The groups treated with dentifrices containing F from NaF/Silica with or without SG had significantly higher(p<0.01) d VHNs than that with F from MFP/DCPD(p<0.01). The a VHNs treated with dentifrice containing both F-SG demonstrated the highest among test groups, indicating that there is an additive benefit in remineralizing the incipient subsurface lesion.
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